[HTML][HTML] Epidermal growth factor receptor (EGFR) inhibitors and derived treatments
R Dziadziuszko, J Jassem - Annals of Oncology, 2012 - Elsevier
Epidermal growth factor receptor inhibitors are used to treat advanced lung cancer patients
for almost a decade. Current knowledge on their role in the first or subsequent lines of
therapy serves as a model for other targeted therapies in development. Several molecular
predictors of outcomes were successfully identified in preclinical and clinical studies.
Evaluation of EGFR-activating mutations is currently used to define biologically distinct
patient subsets with important consequences for prognosis and therapy. Ongoing …
for almost a decade. Current knowledge on their role in the first or subsequent lines of
therapy serves as a model for other targeted therapies in development. Several molecular
predictors of outcomes were successfully identified in preclinical and clinical studies.
Evaluation of EGFR-activating mutations is currently used to define biologically distinct
patient subsets with important consequences for prognosis and therapy. Ongoing …
